Treatment Milestones in Ph+ CML

By working closely with your doctor, you can learn how medication may help you reach your treatment goals for Philadelphia chromosome–positive chronic myeloid leukemia (Ph+ CML).


Achieving a response

Every patient is unique and your doctor will need to discuss the treatment goals that are within your reach. Some common goals include:

  • Getting your blood cell counts back within normal ranges
  • Reducing the number of leukemic cells in your body
  • Reducing the amount of the BCR-ABL protein to a level that is undetectable


Your doctor may talk about achieving what’s called a “molecular response.” This means the number of cells in your body with the BCR-ABL1 gene is going down. The lower the number of cells, the better.


Treatment milestones in Ph+ CML

Once you begin treatment for Ph+ CML, your doctor will have you go for regular blood and bone marrow tests. These tests can help your doctor see how you are responding to your medication. They can also help your doctor determine if you are reaching certain treatment milestones in Ph+ CML.


Your doctor will measure your response to treatment based on the amount of BCR-ABL1 in your blood. The BCR-ABL protein causes the production of leukemic cells.

Treatment Milestones Timeline

The milestones timeline below shows an ideal response to treatment, which your doctor may discuss with you. The illustrations are designed to help you picture how your blood counts may come down over time with treatment. The dots represent the number of BCR-ABL1 cells in the body.


Keep in mind, not every patient will reach these treatment milestones or reach them at the same time. 

Identifying a deep molecular response

While it’s not considered a treatment milestone, your doctor may look for another treatment result called a deep molecular response (DMR) or MR4.5. Your doctor may check to see if you reach this milestone by 5 years. Some patients have reached DMR as early as 1 year.


With DMR, the amount of BCR-ABL1 is considered undetectable or 0.0032% of all the cells in your blood. This means that 1 out of every 32,000 cells has the BCR-ABL1 gene.

TASIGNA may help you reach your treatment goals

Talk to your doctor to determine the treatment goals that are within your reach and how TASIGNA® (nilotinib) capsules may help you get there. Learn more