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Signs & Symptoms

Philadelphia chromosome–positive chronic myeloid leukemia (Ph+ CML)

Ph+ CML Symptoms

Many people are diagnosed in the early stage of Philadelphia chromosome–positive chronic myeloid leukemia (Ph+ CML) and do not have any obvious signs or symptoms. Often Ph+ CML is discovered during a routine blood test when results show the person has an elevated white blood cell count. Some signs and symptoms of Ph+ CML include:

  • Feeling unusually tired
  • Unexplained weight loss
  • Unusual sweating at night
  • Fever
  • Pale skin
  • Pain or a feeling of fullness on the upper left side of the belly area (abdomen), under the ribs

Phases of Ph+ CML

The phases of Ph+ CML are based on the percentage of blast cells (immature white blood cells) as compared with other blood cells in the bone marrow. Most adults living with Ph+ CML are diagnosed in chronic phase, which is the initial phase of the disease.


*Based on World Health Organization (WHO) criteria