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How to Take Treatment


Taking TASIGNA as prescribed by your doctor

The usual dose is 2 capsules in the morning and 2 in the evening, taken 12 hours apart, with water. Your doctor may prescribe a different dose or frequency of taking TASIGNA® (nilotinib) capsules based on your medical situation.



One of the most important things to know about taking TASIGNA is that it should never be taken with food.


Stick to this regimen:

  • Take TASIGNA at least 2 hours after eating
  • Do not eat for at least 1 hour after taking it
  • You may drink water while you are not eating, before or after taking TASIGNA


You may find that it works for you to take TASIGNA as soon as you wake up, and then wait at least an hour to eat breakfast. This way, you will have 12 hours before you need to take your second dose of the day.


Food may enhance your body’s absorption of TASIGNA. If you take TASIGNA with food, it may increase the amount of TASIGNA in your blood in an unpredictable way, possibly to harmful levels. This can cause dangerous side effects such as irregular heart rhythm.

How to take TASIGNA

How to take TASIGNA


Examples of how to time your doses

Example 1: Eat breakfast at 8:00 AM. Take TASIGNA at 10:00 AM.
Eat dinner before 8:00 PM. Take TASIGNA at 10:00 PM before bedtime.

Example 2: Take TASIGNA at 5:00 AM. Eat breakfast at 6:00 AM.
Take TASIGNA at 5:00 PM. Eat dinner at 6:00 PM.

If you are unable to swallow capsules, the contents of each capsule may be mixed in 1 teaspoon of applesauce or apple purée, and swallowed right away (within 15 minutes).

Foods and medicines to avoid while taking TASIGNA

Foods to avoid at all times

Some foods and TASIGNA may interfere with each other. Some may make TASIGNA less effective; others may increase the amount of TASIGNA in your blood and cause unwanted and possibly severe side effects.

foods to avoid

Do not eat grapefruit, drink grapefruit juice, or take supplements containing grapefruit extracts while on TASIGNA. This can raise the levels of TASIGNA in your body in an unpredictable manner.

Medicines to avoid

Before taking TASIGNA, tell your doctor if you are taking any other medicines. This includes medicines prescribed by other doctors you have seen, as well as medicines, herbs, and supplements that you buy without a prescription from a pharmacy, supermarket, or health food store.

  • TASIGNA can interact with many medicines and supplements and increase your chance for serious and life-threatening side effects
  • Please check with your health care team before starting, stopping, or changing any medicine
  • Caution should be used with medicines used to decrease gastric acid, such as esomeprazole
  • If required, antacids should be taken at least 2 hours before or after taking TASIGNA
  • You may need to take different amounts of these medicines or you may need to take different medicines. Your doctor and pharmacist have more information